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Acclaimed filmmaker Lauren Greenfield examines modern greed amid the world of the 1%.

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Persistent localized pain may indicate a pathological bone fracture.

Involvement of the vertebrae may lead to spinal cord compression or kyphosis.

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Myeloma cells produce monoclonal proteins of varying types, most commonly immunoglobulins (antibodies) and free light chains, resulting in abnormally high levels of these proteins in the blood.

Depending on the size of these proteins, they may be excreted through the kidneys. pneumoniae, while common pathogens causing pyelonephritis include E. The greatest risk period for the occurrence of infection is in the initial few months after the start of chemotherapy.

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A mnemonic sometimes used to remember some of the common symptoms of multiple myeloma is CRAB: C = calcium (elevated), R = renal failure, A = anemia, B = bone lesions.

Myeloma has many other possible symptoms, including opportunistic infections (e.g., pneumonia) and weight loss.

Myeloma bone disease is due to the overexpression of receptor activator for nuclear factor κ B ligand (RANKL) by bone marrow stroma. The resultant bone lesions are lytic (cause breakdown) in nature, and are best seen in plain radiographs, which may show "punched-out" resorptive lesions (including the "raindrop" appearance of the skull on radiography).

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